臨床研究等提出・公開システム

Study of the effect of transcranial direct current stimulation on the pyramidal tract function in normal subjects.

Study of direct current stimulation in normal subjects.

2

2 healthy men in their 20s with no neurological history who was obtained for the study.

This study is 2*2 crossover trials, measurement for 2 people completed.

No

(First case) MEP latency (average of 10 waveforms) , MEP amplitude (average of 10 waveforms) , and number of pegs are displayed for real and sham stimulation separately for tDCSpre, tDCSpost, tDCSpost60min. MEP latency (average addition of 10 waveforms) : Real 21.5/21.8/21.9ms, Sham 21.4/21.2/22.2ms MEP amplitude (average addition of 10 waveforms) : Real 331/255/316mV, Sham 228/153/247mV Number of pegs : Real 35/36/34pieces, Sham 35/34/31pieces (2nd case) MEP latency (average of 10 waveforms) , MEP amplitude (average of 10 waveforms) , and number of pegs are displayed for real and sham stimulation separately for tDCSpre, tDCSpost, tDCSpost30min, and tDCSpost60min. MEP latency (average addition of 10 waveforms) : Real 22.2/23.3/22.9/22.6ms, Sham 23/22.5/21.8/22.4ms MEP amplitude (average addition of 10 waveforms) : Real 136/111/141/162mV, Sham 274/145/148/72mV Number of pegs : Real 34/34/37/41pieces, Sham 36/38/40/38pieces

Problems with the test technique and fatigue of the subjects due to long-term measurements led to unreliable measurement results. As only two subjects were measured, this study was unable to shed any light on the results.

May. 19, 2025

No

No

https://jrct.mhlw.go.jp/latest-detail/jRCTs042220008

Hattori Noriaki

Toyama University Hospital

2630 Sugitani Toyama

hattorin@med.u-toyama.ac.jp

Furuya Kota

Toyama University Hospital

2630 Sugitani Toyama

+81-76-434-7850

furuyapt@med.u-toyama.ac.jp

Complete

April. 25, 2022

Interventional

randomized controlled trial

double blind

placebo control

crossover assignment

basic science

1) Japanese healthy applicants, gender doesn`t matter.
2) Over 20 years old and under 85 years old.
3) Right handed.
4) Those who can participate in the study on the specified date after obtaining informed consent.
5) Those whose written consent form for participation in this research can be obtained.

1)Pregnant, potentially pregnant, or breastfeeding person.
2)History of alcoholism or under treatment.
3)History of epilepsy or under treatment.
4)Taking antidepressants,antipsychotics,or hypnotic sedatives for long period.
5)History or current illness of psychiatric and neurological disorders affecting motor function or cognitive function.
6)History or current illness of motor dysfunction of the upper limb due to injury, dosease, deformation or deficient of muscles, bones, or joints.
7)Have serious complications inckuding liver dysfunction, renal
dysfunction and endocrine disorders.
8)Those with medical devices containing magnetic parts or electronic circuits (artificial heart valves, artificial joints, vascular stents, cardiac pacemakers, intracranial metals such as aneurysm clips and shunt tubes that require pressure adjustment, deep brain stimulators, etc.) embedded in the body or body surface (excluding dental fillings).
9)Previous surgeries opening the skull.
10)Those who have magnetic materials in the body or beneath the surface of the body.
11)Those who are judged to be inappropriate by the researchers for participatin the study.

Both

Normal subjects

Brain stimulation by transcranical direct current stimulation.

tDCS

Motor Evoked potential (MEP)

ipsilateral Silent Period (iSP)
Upper limb dexterity (peg task)

+81-76-415-8857

Mar. 14, 2022

none