臨床研究等提出・公開システム

Multi center study of patch test allergens by the Japanese Contact Dermatitis Research Group

Study of patch test allergens

2690

Patients whose skin disorders have been induced by any substance applied to or in contact with the skin. [Japanese baseline series 2015:Patch testing] -Total 2,421cases (Male: 457cases,Female:1,964cases) -Average age 49.4(Male: 48.3,Female:49.6) [Japanese baseline series 2:Patch testing] -Total 269cases (Male: 44cases,Female:225cases) -Average age 47.3(Male:46.0,Female:47.6)

[Japanese baseline series 2015:Number of Patch Test Cases] 2021/8/30-2022/3/31:917cases 2022/4/1-2023/3/31:1257cases 2023/4/1-2023/12/31:247cases [Japanese baseline series 2:Number of Patch Test Cases] 2022/4/1-2023/12/31:269cases

none

[Japanese baseline series 2015:Positive rate] Nickel sulfate 23.7%,Lanolin alcohol 1.0%,Fradiomycin sulfate 3.1%,Potassium dichromate 2.1%,Caine mix 1.4%,Fragrance mix 4.4%,Epoxy resin 2.1%,Paraben mix 1.0%,Balsam of Peru 1.1%,Gold sodium thiosulfate 25.1%,Cobalt chloride 8.4%,p-tert- Butylphenol formaldehyde resin 4.0%,Epoxy resin 1.7%,Dithiocarbamate mix 5.5%,PPD black rubber mix 1.7%,Isothiazolin mix 2.4%,Mercaptobenzothiazole 0.4%,p-Phenylenediamine 7.0%,Formaldehyde 1.5%,Mercapto mix 0.9%,Thimerosal 1.5%,Thiuram mix 3.4%,Urushiol 6.3%,Mercury(II) chloride 3.1% [Japanese baseline series 2:Positive rate] 2-Hydroxyethyl methacrylate 6.3%,Methyl methacrylate 2.6%,Fragrance mix II 2.6%

[Japanese baseline series 2015]Regarding metal allergens, Gold sodium gold thiosulfate and nickel sulfate have maintained high positive rate, suggests the need for some countermeasures in the future. [Japanese baseline series 2]2-Hydroxyethyl methacrylate, methyl methacrylate, and fragrance mix 2 were all found to be useful to apply it with the product together when doing patch tests. In particular, 2-hydroxyethyl methacrylate is the main component of gel nails and is useful for searching for the cause.

April. 01, 2024

https://www.jscia.org/useful_info_jsa.html

No

No

https://jrct.mhlw.go.jp/latest-detail/jRCTs041210060

Yagami Akiko

Fujita Health University Bantane Hospital

3-10-6, Otobashi, Nakagawa-ku,Nagoya, Aichi 454-8509

ayagami@fujita-hu.ac.jp

Ishigaki Naoko

Fujita Health University Bantane Hospital

3-10-6, Otobashi, Nakagawa-ku,Nagoya, Aichi 454-8509

+81-52-321-8171

alergia@fujita-hu.ac.jp

Complete

Aug. 30, 2021

Interventional

single arm study

open(masking not used)

uncontrolled control

factorial assignment

diagnostic purpose

1) Patient has skin disorder induced by any substances and products applied or contacted to the skin.
2) Patient who is willing to comply with the research implementation plan.
3) Patient have signed the consent form approved by the Ethics Review Committee of the Fujita Health University.

A patient whom a doctor judges that participation in research is inappropriate.

Both

Allergic contact dermatitis

Patch testing with allergen (unapproved in Japan) to the patient of suspected contact dermatitis.

Contact dermatitis

Patch test allergen

D017449

D010328

Survey analysis of positive rate of JBS, JBS2

+81-562-93-2865

July. 08, 2021

none