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Quantitative evaluation of anatomical structures of the whole body using CT in a standing or sitting position: comparison with CT in a supine position (VolCT)

Quantitative evaluation of anatomical structures of the whole body using CT in a standing or sitting position (VolCT)

208

The total number of study subjects was 208, with 2 incomplete cases and 206 complete cases (101 males and 105 females, median age 48.5 (30-87) years).

Subject enrollment and intervention period was from June 28, 2017 to June 2, 2021. Total enrollment was 206 subjects.

During the clinical trial, no illnesses, or other diseases (unfavorable health changes, all serious adverse events, and death) related to the clinical study occurred.

A study of the workflow of standing CT in 32 healthy subjects showed a 56 % reduction in total access time for standing CT compared with supine CT (standing: 41 +/- 9 sec vs supine: 91 +/- 15 sec, P < 0.001). In addition, the area of the superior vena cava was 80 % smaller in the upright position compared with the supine position, the area of the inferior vena cava at the level of the diaphragm was comparable and the area of the inferior vena cava was 37 % larger. In a study of 100 healthy subjects who underwent supine, standing or sitting CT and pulmonary function test (PFT) on the same day, inspiratory and expiratory total, upper and lower lobe lung volumes were significantly higher in the standing position than in the supine position (5.3-14.7% increase, P < 0.001). However, inspiratory right middle lobe volumes were similar in all three positions, while expiratory right middle lobe volumes were significantly reduced in the standing/sitting position compared with the supine position (16.3/14.1% reduction, P < 0.0001). Standing/sitting CT also showed a higher correlation with total lung volume and maximal inspiratory capacity on PFT than supine CT. In a study of 139 healthy subjects examining changes in the position of the pelvic floor in the supine and upright positions, the bladder neck descended by approximately 6 mm in men and 10 mm in women from the supine to the upright position. Pelvic floor mobility was greater in women than in men. The anorectal junction tended to descend in the standing position in older women.

The area of the vena cava, lung volume and position of the pelvic floor in healthy subjects in the standing and sitting positions were revealed to be different in the standing, sitting and supine positions. This data will provide a basis for the early detection of disease and the determination of its causes. The examination time for standing CT is 56% shorter than for supine CT and the examination is less invasive.

Mar. 01, 2024

July. 31, 2019

https://pubmed.ncbi.nlm.nih.gov/31503082/

No

N/A

https://jrct.mhlw.go.jp/latest-detail/jRCTs032180267

Jinzaki Masahiro

Keio University School of Medicine

35 Shinanomachi, Shinjuku-ku, Tokyo

jinzaki@rad.med.keio.ac.jp

Yokoyama Yoichi

Keio University School of Medicine

35 Shinanomachi, Shinjuku-ku, Tokyo

+81-3-5363-3582

yyokoyama@rad.med.keio.ac.jp

Complete

June. 28, 2017

Interventional

non-randomized controlled trial

open(masking not used)

active control

crossover assignment

diagnostic purpose

Healthy male or female volunteers, aged from 30 to 89, who understand the purpose of this study

1. Known or possible pregnancy
2. Subjects with newly developed symptoms of any diseases
3. Subjects who are not able to undergo CT in a standing or sitting position
4. Subjects who do not provide written informed consent

Both

Healthy volunteers

Whole body scan using both supine CT and upright CT performed. In addition, other examination (respiratory function test or electrocardiogram or ultrasonography) conducted.

Morphological parameters on images

Examination time, Safety during scanning, Difficulty in examination

+81-3-5363-3503

Feb. 28, 2019

none