臨床研究等提出・公開システム

Search for abnormalities of fundus blood vessels in moyamoya disease

Search for abnormalities of fundus blood vessels in moyamoya disease

17

The mean age (standard deviation) was 46.7 (11.9) years, with 4 males and 13 females

The pace of enrollment was slower and less frequent than originally anticipated: 17 patients with Moyamoya disease were enrolled, 17 of whom underwent fundus fluorescence angiography, and one of whom was terminated due to nausea as an adverse reaction during the examination.

One patient developed nausea and wheals as an allergic reaction to indocyanine green contrast medium, so subsequent fluorescein fluoroscopy was discontinued.

Of the 16 patients who underwent fluorescence angiography, 2 were excluded from the analysis because of a history of obvious retinal vascular lesions. Fourteen patients were included in the analysis, of which 4 (28.6%) had abnormal retinal vascular structures..Abnormalities of retinal vascular structure included capillary dilatation, loop-like structures of peripheral vessels, and arteriovenous and venous shunts.

Of the patients with moyamoya disease, 4/14 (28.6%) had abnormal retinal vasculature. Abnormal retinal vasculature included capillary dilatation, looping of peripheral vessels, and arteriovenous and venous shunts.Moyamoya disease can cause changes in retinal vasculature.

Jan. 31, 2025

No

NO

https://jrct.mhlw.go.jp/latest-detail/jRCTs031200402

Akiyama Hideo

Gunma University Hospital

3-39-15, Showa-machi, Maebashi-shi, Gunma

akiyamah47@gunma-u.ac.jp

Akiyama Hideo

Gunma University Hospital

3-39-15, Showa-machi, Maebashi-shi, Gunma

+81-27-220-8338

akiyamah47@gunma-u.ac.jp

Complete

Mar. 08, 2021

Interventional

single arm study

open(masking not used)

no treatment control/standard of care control

single assignment

screening

Moyamoya disease patient group
1) Patients diagnosed with moyamoya disease (regardless of stage)
2) Patients aged 20 years or older (regardless of gender)
3) Patients with no previous history of fundus vascular disease
4) Outpatients
5) Patients who have given written consent to participate in this study.

Normal fundus group
1) Patients who have undergone general ophthalmologic examination (visual acuity test, refraction test, intraocular pressure test, anterior segment and fundus examination), fundus photography, retinal optical coherence tomography, retinal optical coherence angiography, and laser speckle flow graphing examination at our ophthalmology department.
2) Patients who do not have fundus lesions in one or both eyes based on the above tests.
3) Patients who are 20 years old or older (regardless of gender)
4) Outpatients

Moyamoya disease patient group
1) Patients with a history of hypersensitivity to fluorescein and indocyanine green
2) Patients with a history of iodine hypersensitivity
3) Patients with a history of other serious drug allergies
4) Narrow-angle eyes
5) Pregnant women and lactating women
(6) Patients within 6 months of angina pectoris or myocardial infarction attack
7) Hepatic dysfunction
8) Patients with a history of stroke or cerebrovascular surgery within 6 months
9) Other patients who are judged by the physician to be inappropriate for the study.

Normal fundus group
(1) Patients who do not wish to cooperate in the research by disclosing the research information through opt-out

Both

Moyamoya disease

For fluorescein fundus angiography, 500 mg of fluorescein (5 ml vial of aqueous solution containing 500 mg of fluorescein) and 25 mg of Ophthagreen (2 ml of blue indocyanine green) are dissolved in 2 ml of distilled water for injection and injected through the forearm of the elbow vein. In daily practice, diabetic retinopathy can be treated by using a diabetic retinal imaging system (optos). In daily practice, it is used for the diagnosis of diabetic retinopathy, uveitis, occlusive retinal vascular disease, and age-related macular degeneration.

Moyamoya disease

058

Prevalence of Retinal Vasculature Abnormalities in Patients with Moyamoya Disease on Fluorescence Fundus Angiography

Retinal blood vessel density, area of central fovea no-reflux area, subcentral foveal retinal thickness, and subcentral foveal choroidal thickness obtained from retinal optical coherence tomography and retinal optical coherence angiography will be compared between groups of patients with moyamoya disease and normal fundus.

+81-27-220-8740

Mar. 01, 2021

none