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Examination of Aroma Essencial Oil Inhalation Effect on Post Oral Surgery Nausea Severity: Single-Blind Randomized Controlled Trial

Examination of aroma inhalation effect on post oral surgery nausea

182

Age ranged from 20 to 70 years, with a median (interquartile range) of 32 (25-45) years. Approximately 63% were female and 37% were male.

Of the 190 patients who gave consent, 8 patients were excluded: 4 patients because the surgery was canceled or postponed due to the patient's physical or mental health problems, and 4 patients because the researcher was unable to perform the study due to an infection or other reason. As initially planned, 182 patients were enrolled in the study. The allocators assigned 93 patients to the aroma intervention group and 89 to the control group. Of these, 32 patients in the aroma intervention group and 25 in the control group who complained of postoperative nausea received the intervention.

No adverse events were observed during the entire study period.

Primary outcome The mean (standard error) change in nausea severity after the first inhalation was -19.15 (3.67) in the Aroma group and -2 (1.08) in the control group. The mean change (standard error) was -24.46 (3.88) in the aromatherapy group and -0.5 (2.35) in the control group, indicating a significant decrease in nausea severity in the aromatherapy group (p<0.001). Secondary outcomes. The rate of antiemetic use was 30.77% in the aromatherapy intervention group and 52.38% in the control group, but the difference was not statistically significant (p=0.151). The antiemetic agents used were intravenous metoclopramide in 15 patients, oral metoclopramide in 2 patients, and an intravenous combination of ondansetron and metoclopramide in 2 patients. Regarding patient satisfaction, satisfaction was significantly higher in the aroma intervention group.

This study found that inhalation of a blend of peppermint, ginger, and lavender aromatic oils can reduce the severity of nausea after oral surgery under general anesthesia and is an effective treatment with high patient satisfaction.

Mar. 31, 2025

No

No

https://jrct.mhlw.go.jp/latest-detail/jRCTs011210021

Kamekura Nobuhito

Hokkaido University Hospital

Kita14, Nishi5, Kita-Ku, Sapporo Hokkaido

salakame@den.hokudai.ac.jp

Ishikawa Emi

Hokkaido University Hospital

Kita14, Nishi5, Kita-Ku, Sapporo Hokkaido

+81-11-706-4336

esmuin128@den.hokudai.ac.jp

Complete

July. 16, 2021

Interventional

randomized controlled trial

single blind

placebo control

factorial assignment

treatment purpose

1. Patients scheduled to undergo oral surgery under general anesthesia at Surgical Center or Center for Oral Surgery of Hokkaido University Hospital
2. Age 20+
3. ASA physical status class 1 or 2
4. Written informed consent

1. Lack of judgment, such as intellectual disability
2. Allergy to the aroma essential oil
3. Olfactory disorder
4. Hemorrhagic diathesis
5. ICU management after general anesthesia
6. Scheduled to administer intraoperative antiemetic prophylaxis
7. Judged by the primary sponser to be inappropriate as research subjects

Both

Postoperative nausea

Inhale aroma essential oils (blends) of lavender, ginger and peppermint diluted to 1% at the time of postoperative nausea. The inhalation time is 2 minutes, followed by another 2 minutes of inhalation after assessment of nausea severity. The control group uses only purified water for similar inhalation.

Amount of change in the severity of nausea with and without aroma essential oil at the time of postoperative nausea.

Antiemetics use rate, drug name and dose used, patient satisfaction, adverse events.

+81-11-706-7934

July. 05, 2021

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