臨床研究等提出・公開システム

Islet transplantation for insulin-dependent diabetes mellitus

Islet transplantation for insulin-dependent diabetes mellitus

Sekijima Yoshiki

soejima yuuji

Shinshu University School of Medicine

3-1-1,Asahi,Matsumoto,Nagano

ysoejima@shinshu-u.ac.jp

Yokomae Mamoru

Shinshu University Hospital

3-1-1 Asahi Matsumoto Nagano Japan

+81-263372751

saiseijimu@shinshu-u.ac.jp

Interventional

single arm study

open(masking not used)

uncontrolled control

single assignment

treatment purpose

1) A patient needs insulin treatment because of significantly reduced endogenous insulin.
2) Uncontrol blood glucose under the treatment by a diabetes specialist.
3) Under 75 years old
4) The patient, the family, and the attending physician agree with islet transplantation after the informed consent about both pancreatic transplantation and islet transplantation.
5) More than 5 years have passed since the onset of the disease.

1) severe heart and/or liver disease
2) alcoholism
3) infection
4) malignant disease
5) severe obesity (BMI>25kg/m2)
6) retinopathy
7) other severe illness

Both

insulin-dependent diabetes mellitus

islet allograft transplantation

C566645

Diabetes Mellitus, Type 1

HbA1c<7.4% a year after islet transplantation and percentage of recipients without hypoglycemia 90 to 365 days after islet transplantation

HbA1c<7.4% two year after islet transplantation and no hypoglycemia 90 to 730 days after islet transplantation
no hypoglycemia 90 to 730 days after islet transplantation
HbA1c<7.4% two year after islet transplantation
HbA1c<6.9% two year after islet transplantation
Insulin independent two year after islet transplantation

Recruiting

+81-75-753-4680

June. 09, 2025