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A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis (CVAY736S12201)

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis (CVAY736S12201)

Inoue Ayano

Novartis Pharma. K.K.

Toranomon Hills Mori Tower 23-1, Toranomon 1-chome Minato-ku, Tokyo 105-6333, Japan

rinshoshiken.toroku@novartis.com

Inoue Ayano

Novartis Pharma. K.K.

Toranomon Hills Mori Tower 23-1, Toranomon 1-chome Minato-ku, Tokyo 105-6333, Japan

+81-120-003-293

rinshoshiken.toroku@novartis.com

Recruiting

Sept. 15, 2025

Interventional

randomized controlled trial

double blind

active control

parallel assignment

treatment purpose

- Male and female participants >= 18 and =< 70 years (at the time of the screening visit).

- Diagnosis of systemic sclerosis, as defined by the 2013 American College of Rheumatology/ European League Against Rheumatism (ACR/EULAR) classification criteria for SSc (van den Hoogen et al 2013) and meet the dcSSc subset classification according to LeRoy (LeRoy 1988)

- Disease duration of =< 60 months (defined as time from the first non-Raynaud phenomenon manifestation, e.g., puffy hands, scleroderma, digital ulcers, arthralgia, dyspnea)

- mRSS units of >= 15 and =< 45 at the time of the screening visit

- Active disease that meets at least one of the following criteria at screening:
-Disease duration of =< 18 months defined as time from the first non-Raynaud phenomenon manifestation
-Increase in mRSS of >= 3 units compared with the most recent assessment performed within the previous 6 months
-Involvement of one new body area and an increase in mRSS of >= 2 units compared with the most recent assessment performed within the previous 6 months
-Involvement of two new body areas within the previous 6 months
-Elevated acute phase reactants (ESR) >= 30 mm/hr or high-sensitivity C-reactive protein (hsCRP) >= 6 mg/L)
-Presence of SSc-interstitial lung disease (ILD) and ATA autoantibody positivity
-Modified EUSTAR disease activity index (mDAI) >= 2.5

- Participant must be positive for at least one of the following autoantibodies:
-anti-topoisomerase I (ATA) (also known as anti-SCL-70)
-anti-RNA polymerase III (anti-RNAP3)
-anti-nuclear antibody (ANA) (>= 1:80) Participants who are positive only for ANA (while being negative for both ATA /anti-RNAP3) will be limited to 30% of the overall randomized study population.

- Rheumatic disease other than dcSSc, including limited cutaneous disease (lcSSc) or sine scleroderma at the screening visit. Secondary Sjogren's disease and scleroderma myopathy are not exclusionary.
- Positive anti-centromere antibody (ACA+) without positive ATA or anti-RNAP3 autoantibody result at the screening visit
- Previous improvement (decrease) in mRSS > 10 units
- Pulmonary disease with FVC =< 50% of predicted or diffusing capacity of the lung for carbon monoxide (DLCO, corrected for hemoglobin) =< 40% of predicted at the screening visit
- WHO Functional Class 3 or higher assessment for pulmonary arterial hypertension (PAH, as defined on right heart catheterization), receiving IV therapy for PAH or evidence of other moderately severe pulmonary disease
- Participants treated with cyclophosphamide within 12 weeks prior to Baseline.
- Prior use of a B-cell depleting therapy other than ianalumab (e.g., rituximab, other anti-CD20 mAb, anti-CD22 mAb, or anti-CD52 mAb) administered within 36 weeks prior to randomization, or as long as B cell count is less than the lower limit of normal or baseline value prior to receipt of B cell-depleting therapy (whichever is lower).
- Treatment with biologic agents, such as intravenous immunoglobulin or monoclonal antibodies, including marketed drugs, within 12 weeks or 5 half-lives (whichever is longer) prior to baseline visit, unless explicitly allowed in inclusion criteria.
- Treatment with any investigational agent within =< 4 weeks (or 5 half-lives of the investigational drug, whichever is longer) of the baseline visit.
- Use of anti-fibrotic agents including colchicine, D-penicillamine, pirfenidone, or tyrosine kinase inhibitors (e.g., nintedanib, nilotinib, imatinib, dasatinib) in the 4 weeks prior to baseline visit. Patients with SSc-ILD requiring antifibrotics for management of ILD during the study, as per investigator judgement, should be excluded.
- Previous treatment with chlorambucil, bone marrow transplantation or total lymphoid irradiation.
- Women of childbearing potential, defined as all women physiologically capable of becoming pregnant from menarche until becoming post-menopausal, unless they are using highly effective methods of contraception (failure rate < 1% per year) while taking study treatment and for 6 months after stopping study treatment.

Both

Diffuse Cutaneous Systemic Sclerosis

Experimental: VAY736 (Ianalumab)
Treatment Period 1:
Ianalumab subcutaneous (s.c.) injection as defined in the protocol
Treatment Period 2:
Open-label Ianalumab subcutaneous (s.c.) injection as defined in the protocol

Placebo Comparator: Placebo
Treatment Period 1:
Placebo to Ianalumab subcutaneous (s.c.) injection as defined in the protocol
Treatment Period 2:
Open-label Ianalumab subcutaneous (s.c.) injection as defined in the protocol

3/5 rCRISS25 response at Week 52

+81-3-5550-7158

July. 15, 2025

Yes

Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent expert panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations. This trial data is currently available according to the process described on www.clinicalstudydatarequest.com.

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