臨床研究等提出・公開システム

Scientific Title	A double-blind, randomized, controlled trial to verify the efficacy of elastic compression stockings for acute proximal deep vein thrombosis (COMPRESSION Trial)
Public Title	A double-blind, randomized, controlled trial to verify the efficacy of elastic compression stockings for acute proximal deep vein thrombosis (COMPRESSION Trial)

Contact for Scientific Queries	Name	Yamashita Yugo
	Affiliation	Kyoto University Hospital
	Address	54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto
	Telephone	+81-75-751-4255
	E-mail	yyamashi@kuhp.kyoto-u.ac.jp
Contact for Public Queries	Name	Yamashita Yugo
	Affiliation	Kyoto University Hospital
	Address	54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto
	Telephone	+81-75-751-4255
	E-mail	yyamashi@kuhp.kyoto-u.ac.jp

Recruitment status	Recruiting

Anticipated date of first enrollment		May. 12, 2026
Target sample size		200
Study Type		Interventional
Study Design	allocation	randomized controlled trial
	masking	double blind
	control	placebo control
	assignment	parallel assignment
	purpose	prevention purpose
Key inclusion & exclusion criteria	Inclusion Criteria	Patients diagnosed with first acute symptomatic proximal deep vein thrombosis by imaging examinations
	Exclusion Criteria	Patients who cannot use elastic compression stockings Patients with a life expectancy of 6 months or less Patients who have undergone thrombolytic therapy Patients who have undergone invasive thrombectomy, including endovascular therapy Patients who are deemed inappropriate by their attending physician
	Age Minimum	18age old over
	Age Maximum	No limit
	Gender	Both
Health Condition(s) or Problem(s) Studied		Deep vein thrombosis
Intervention(s)		Elastic compression stockings
Health Condition(s) Keyword		Deep vein thrombosis, Post-thrombotic syndrome
Intervention(s) Keyword		Compression, Stockings
Health Condition(s) Code		D020246
Intervention(s) Code		D053828
Primary Outcome(s)		Post-thrombotic syndrome at 2 years
Secondary Outcome(s)		Pain assessment at 3 months Calf and ankle circumference at 3 months Recurrent venous thromboembolism during follow-up Major bleeding during follow-up All-cause mortality during follow-up Adverse events attributable to compression stockings during follow-up Adherence to compression stockings during follow-up

Secondary Sponsor

Secondary Sponsor

Name of Certified Review Board	Kyoto University Certified Review Board
Address	53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto, Kyoto
Telephone	+81-75-366-7618
E-Mail	ethcom@kuhp.kyoto-u.ac.jp
Approval Status	Approval
Date of approval	April. 27, 2026

Plan to share IPD	No

Countries of Recruitment（Except Japan）	none

History of Changes

List of change history