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Evaluation of the Effect of Simultaneous Injection of Contrast Material and Saline on Image Quality in Contrast-Enhanced CT

Effect of Simultaneous Injection of Contrast Material and Saline on Image Quality in Contrast-Enhanced CT

Noda Yoshifumi

Graduate School of Medicine, Gifu University

1-1 Yanagido, Gifu, Gifu, Japan

noda.yoshifumi.g9@f.gifu-u.ac.jp

Noda Yoshifumi

Graduate School of Medicine, Gifu University

1-1 Yanagido, Gifu, Gifu, Japan

+81-58-230-6437

noda.yoshifumi.g9@f.gifu-u.ac.jp

Recruiting

Mar. 11, 2026

Interventional

randomized controlled trial

single blind

dose comparison control

parallel assignment

diagnostic purpose

1 Patients aged 18 years or older at the time of obtaining informed consent (regardless of sex).
2 Patients scheduled to undergo contrast-enhanced CT at the time of obtaining informed consent.
3 Patients who have provided written informed consent.

1 Patients weighing over 80 kg at the time of informed consent.
2 Patients with a history of allergy-like reactions to contrast media.
3 Pregnant patients.
4 Patients with eGFR < 30 mL/min/1.73 m2.
5 Patients who are deemed unsuitable for participation in this study by the investigator for any other reason.

Both

All conditions requiring body contrast-enhanced CT

Written informed consent will be obtained from participants who are considered potentially eligible for this study. Participants will then be randomly assigned to undergo either the conventional contrast injection method (conventional method) or the simultaneous injection of contrast material and saline (simultaneous injection method), which will serve as the control group and the study group, respectively.

Quantitative evaluation: CT attenuation values, image noise, and signal-to-noise ratio (SNR).
Qualitative evaluation: Visual assessment by radiologists, including image quality, lesion and organ conspicuity, and diagnostic performance.

None

+81-58-230-6059

Mar. 10, 2026

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