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Re-examination of the right colon with narrow band imaging after conventional forward view examination: an open-label randomized control trial

TWICE trial

Imai Kenichiro

Shizuoka Cancer Center

1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka

ke.imai@scchr.jp

Kimura Hidenori

Shiga University of Medical Science Hospital

Seta-Tsukinowa-cho,Otsu City,Shiga

+81-77-548-2217

kimura64@belle.shiga-med.ac.jp

Recruiting

May. 24, 2023

Interventional

randomized controlled trial

open(masking not used)

active control

parallel assignment

diagnostic purpose

Asymptomatic patients undergoing colonoscopy for colorectal cancer screening or polyp surveilance

(1)Prior colonic resection
(2)Inflammatory bowel disease, polyposis syndrome
(3)Irreversible coagulopathy and thrombocytopenia
(4)Pregnant woman
(5)Infeasibility of suspending antithrombotic drugs

Both

colorectal adenomas, colorectal cancer

Additional forward view examination in the right colon with narrow-band imaging
(Control group)
Standard withdrawal colonoscopy group;
Standard forward view examination in the whole colon with white-light imaging
(Test group)
Second forward view with narrow-band imaging group;
Second forward view examination of the right colon with narrow-band imaging after the first right-colon examination with white-light imaging

Adenoma detection rate in the right colon

Adenoma detection rate of the whole colon
Additional adenoma detection rate at the second observation
Total number of adenomas detected in each group
Adverse events
Predictors for adenoma detection rate in the right colon
Recommended surveillance interval according to guidelines
Performance evaluation of colonoscopy in narrow-band imaging observation
Serrated polyp detection rate in the right colon
Polyp (adenoma or serrated polyp) detection rate in the right colon
Total number of adenomas and serrated polyps detected in each group

+81-55-989-5222

April. 03, 2023

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