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Olfactory and Gustatory Dysfunction After Stroke and Their Associations with Eating Behavior and Rehabilitation Outcomes: An Exploratory Cross-Sectional Study

A Study of Olfactory and Gustatory Dysfunction and Its Relationship with Eating and Rehabilitation After Stroke

Otaka Yohei

Fujita Health University hospital

1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi

rehabmed@fujita-hu.ac.jp

Maeda Genki

Fujita Health University hospital

1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi

+81-562-93-2167

rehabmed@fujita-hu.ac.jp

Recruiting

Oct. 13, 2026

Observational

non-randomized controlled trial

open(masking not used)

uncontrolled control

other

Patients with first-ever subacute stroke admitted to the Department of Rehabilitation Medicine at Fujita Health University Hospital who meet all of the following criteria:
1. Adults aged 18 years or older.
2. Patients with first-ever subacute stroke.
3. Patients who can maintain a sitting position with back support.
4. Patients who have received sufficient information about the study and provided written informed consent.

Patients meeting any of the following criteria will be excluded:
1. Inability to maintain a sitting position even with back support.
2. Inability to understand or follow instructions from physicians or therapists.
3. History of epilepsy.
4. Pregnancy.
5. Mini-Mental State Examination (MMSE) score of 23 or lower.
6. Impaired consciousness.
7. Aphasia that interferes with communication.
8. Presence of a nasogastric tube.
9. Nasal disorders that may affect olfactory assessment.
10. History or diagnosis of Parkinson's disease.
11. History of traumatic cerebral contusion.
12. Diagnosis of multiple system atrophy.
13. Current smoking.

Both

Stroke

Not applicable (Non-interventional observational study)

Stroke, Cerebral Infarction, Intracerebral Hemorrhage, Olfactory Dysfunction, Gustatory Dysfunction

D020521

Prevalence of olfactory and gustatory dysfunction in patients with stroke.
Olfactory function will be assessed using Open Essence, and gustatory function will be assessed using the Taste and Smell Survey (TSS) questionnaire. The presence or absence of olfactory and gustatory dysfunction will be determined based on the respective assessment results, and the prevalence of each dysfunction will be calculated.

1. Association between olfactory and gustatory function and cognitive function, assessed using MMSE, MoCA-J, FAB, and other cognitive assessments.
2. Association between olfactory and gustatory function and motor performance, assessed using FMA, BBS, FAC, TUG, and walking speed.
3. Association between olfactory and gustatory function and dietary intake, including food consumption and energy intake.
4. Agreement and discrepancy between subjective olfactory and gustatory assessments using questionnaires and objective test results.
5. Longitudinal changes in olfactory and gustatory function between admission and discharge.
6. Association between olfactory and gustatory function and rehabilitation outcomes, including changes in motor function, cognitive function, walking ability, and activities of daily living.
Assessments will be conducted within 10 days after admission and within 10 days before discharge, as applicable.

+81-562-93-2865

Sept. 29, 2026

No

There is no plan to share anonymized individual participant data with external researchers. All collected data will be managed appropriately in accordance with the research protocol.

none