臨床研究等提出・公開システム

Evaluation of neuroplasticity and molecular profile of plasma exosomes after neurorehabilitation for Parkinson's disease

Evaluation of neuroplasticity and biomarker after neurorehabilitation for Parkinson's disease

Ueno Yuji

University of Yamanashi

Shimokato 1110, Chuo, Yamanashi

uenoy@yamanashi.ac.jp

Morishima Yuto

University of Yamanashi

Shimokato 1110, Chuo, Yamanashi

+81-55-273-9896

ymorishima@yamanashi.ac.jp

Recruiting

Dec. 13, 2024

Interventional

single arm study

open(masking not used)

uncontrolled control

single assignment

other

1) PD patients diagnosed by a neurologist based on the UK Parkinson's Disease Society Brain Bank
2) PD patients currently attending our outpatient clinic
3) Yahr severity level 3 or less

1) Patients under 20 years of age
2) Patients with moderate or higher cognitive function (MMSE < 24)
3) Patients with contraindications for MRI due to pacemakers, metal in the body, or claustrophobia
4) Patients for whom aerobic exercise is deemed inappropriate due to unstable hypertension, diabetes, cerebrovascular disease, heart disease (ischemic heart disease, arrhythmia, heart failure, etc.), peripheral arterial occlusive disease, orthostatic hypotension, pulmonary disease, etc.
5) Patients with neurological or orthopedic diseases who cannot undergo rehabilitation using stretching or an exercise bike
6) Patients with mental disorders such as depression diagnosed by a psychiatrist, or those with significant mental symptoms

Both

Parkinson's disease

Compared to regular rehabilitation aimed at maintaining daily life and ADL, the rehabilitation in this study focuses on active aerobic exercise, mainly in the sitting and standing positions. Meanwhile, the therapist performs muscle stretches and alignment corrections (body segments and body axes) according to the individual needs of the patient, as well as whole-body coordination, including increasing or decreasing the amount of assistance for unstable elements. In this respect, it differs from the patient simply doing exercises on his or her own.

Parkinson's disease, exosomes, functional MRI, extracellular vesicles

Neurorehabilitation

D010300

D000066530

Neuroplasticity determined by comparing head MRI before and after neurorehabilitation and molecular mechanisms related to neuroplasticity determined by integrated analysis of changes in blood exosome profiles

1) Neuroplasticity obtained by comparing head MRI before and after neurorehabilitation
2) Changes in blood exosome profile (microRNA, mRNA, protein, metabolites, etc.)
3) Changes in PD-related evaluation items
HDS-R, MMSE
UPDRS part I, II, III, IV
Beck Depression Scale
Wearing-off Questionnaires19
Sit to stand-5
Time up and go test
Functional reach test
Mini-Bestest
Falls efficacy scale-International

+81-552739896

Nov. 08, 2023

Yes

The patient is informed of the procedure using a consent form at the neurology outpatient clinic. The patient signs a special consent form.

None