臨床研究等提出・公開システム

Sevoflurane vs Remimazolam and Postoperative Inflammatory Biomarkers After Mandibular Third Molar Extraction Under General Anesthesia

Comparison of Postoperative Inflammatory Biomarkers Between Sevoflurane and Remimazolam in General Anesthesia for Third Molar Extraction

Matsumura Tadashi

Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry

2-1-1 Kitasenzoku, Ota-ku, Tokyo, Japan

dt2270matsumura@dent.showa-u.ac.jp

Matsumura Tadashi

Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry

2-1-1 Kitasenzoku, Ota-ku, Tokyo, Japan

+81-3-3787-1151

dt2270matsumura@dent.showa-u.ac.jp

Pending

July. 09, 2026

Interventional

randomized controlled trial

open(masking not used)

active control

parallel assignment

treatment purpose

Patients who underwent third molar extraction under general anesthesia at Showa University Dental Hospital (Department of Oral and Maxillofacial Surgery or Medical-Dental Collaborative Dentistry Unit).
Male and female patients aged 18 years or older.

Concomitant oral and maxillofacial surgery procedures other than tooth extraction performed at the same time as third molar extraction.
History of jaundice or unexplained fever after exposure to halogenated inhalational anesthetics.
Patients with glaucoma.
Intravenous administration of analgesic-related drugs other than remifentanil and acetaminophen.
Additional intraoperative local anesthetic administration.
Use of more than three local anesthetic cartridges per third molar (per tooth).
Use of regional nerve block anesthesia in addition to infiltration anesthesia.

Both

Impacted mandibular third molar

Selection of anesthetic agents
Preoperative and postoperative blood sampling

D000077149

Change in serum IL-6 concentration from preoperative baseline to 24 hours postoperatively .

Inflammation-/stress-related outcomes
CRP level on postoperative day 1
Postoperative pain and analgesic use
VAS scores at 2 hours and 24 hours postoperatively
Rescue analgesic use up to 24 hours postoperatively: proportion of patients requiring rescue analgesia and number of administrations (intravenous flurbiprofen or intravenous acetaminophen)
Perioperative hemodynamics and recovery outcomes
Range of variation in mean arterial pressure and heart rate intraoperatively and after leaving the operating room
Time from the end of anesthesia to awakening (able to follow commands)
Time from leaving the operating room to return to the ward or clearance for discharge (as applicable)
Association between cytokines and pain-related outcomes
Association between IL-6 and VAS scores at 2 and 24 hours postoperatively

+81-3-3784-8129

No

none