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Sugammadex dosing based on ideal or actual body weight in underweight patients.

Sugammadex dosing based on ideal or actual body weight in underweight patients.

32

None

Recovery from deep neuromuscular block in underweight patients showed no significant difference in the time to achieve a TOF ratio of ≥90% between sugammadex dosed on actual body weight and on ideal body weight.

Although no significant difference was observed, dosing based on actual body weight tended to prolong the recovery time by approximately 20% compared with dosing based on ideal body weight.

No

https://jrct.mhlw.go.jp/latest-detail/jRCT1031230452

Sato Hanae

Nihon University School of Medicin

tokyo itabashi ooyaguchikamimachi 30-1

nakamura.hanae@nihon-u.ac.jp

Sato Hanae

Nihon University School of Medicin, Department of Anesthesiology

tokyo itabashi ooyaguchikamimachi 30-1

+81-3-3972-8111

nakamura.hanae@nihon-u.ac.jp

Complete

Nov. 19, 2023

Interventional

randomized controlled trial

single blind

dose comparison control

parallel assignment

treatment purpose

BMI below 18.5
ASA-PS= 1-3

ppatient who is allergic to muscle relaxants
patient who has neuromuscular diseases
patient who has moderate to severe liver function failure
Patients with hypoalbuminemia
Patients taking medications that affect the muscle relaxant effect
Patients who are deemed inappropriate as research subjects by the principal investigator

Both

Patients undergoing general anesthesia

Sugammadex will be administered in two doses: a real-weight group and an ideal-weight group.

Time from sugammadex administration to TOFR=90%.

+81-3-3972-8111

Oct. 04, 2023

none