Development and Preliminary Evaluation of the Efficacy and Safety of Video-Assisted Group Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder (VOCT)
Development and Preliminary Evaluation of the Efficacy and Safety of Video-Assisted Group Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder (VOCT)
Mitamura Yasue
National Center for Neurology and Psychiatry
4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan
+81-42-341-2711
ymitamura@ncnp.go.jp
Mitamura Yasue
National Center for Neurology and Psychiatry
4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan
+81-42-341-2711
ymitamura@ncnp.go.jp
Recruiting
Feb. 09, 2026
15
Interventional
single arm study
open(masking not used)
uncontrolled control
single assignment
treatment purpose
Study 1:
1) Age 18 or older at the time of consent acquisition
2) Diagnosed with obsessive-compulsive disorder by a primary physician and currently undergoing treatment
3) Permission to participate in this study is obtained from the primary physician
4) Able to respond to interviews online
5) Understands the purpose and content of this study and provides written informed consent to participate voluntarily
6) Consent to not share the program and its materials developed by the research team with others
Study 2:
1) Aged 18 years or older and 65 years or younger at the time of consent acquisition
2) Currently receiving outpatient treatment at this hospital for a diagnosis of obsessive-compulsive disorder
3) Y-BOCS-SR score of 8 points or higher
4) Has obtained permission from their primary physician to participate in this study
5) Understands the purpose and content of this study and has provided written informed consent to participate voluntarily
Study 1:
1) Individuals deemed unsuitable for this study by the principal investigator
Study 2:
1) Individuals exhibiting significant suicidal ideation at the pre-intervention assessment stage
2) Individuals exhibiting significant manic episodes at the pre-intervention assessment stage
3) Individuals for whom weekly attendance during the intervention period is known to be difficult in advance
4) Individuals scheduled to receive other structured psychotherapy (excluding supportive therapy) during the intervention period
5) Individuals with physical illness or severe cognitive impairment at the pre-intervention assessment point that would make participation in group cognitive behavioral therapy difficult
6) Individuals who received treatment with structured psychotherapy, modified electroconvulsive therapy, or transcranial magnetic stimulation (excluding medication) within 3 months prior to the pre-intervention assessment.
7) Individuals with difficulty accessing the internet or operating basic digital devices.
8) Other individuals deemed unsuitable for this study by the principal investigator.
18age old over
65age old under
Both
Obsessive- Compulsive Disorder
Study 1: Not applicable.
Study 2: A video-assisted group cognitive behavioral therapy (CBT) program for obsessive-compulsive disorder (OCD), developed based on the Ministry of Health, Labour and Welfare's Cognitive Behavioral Therapy Manual for Obsessive-Compulsive Disorder, will be conducted face-to-face once a week. During the 12-14 week intervention period, 12 face-to-face group sessions of approximately 90 minutes each week (with 4-10 participants) will be conducted. For the semi-structured interview assessments conducted post-intervention and at the follow-up point, online assessment will be permitted upon confirmation of the participant's preference and with the attending physician's approval.
Obsessive- Compulsive Disorder
Cognitive Behavioral Therapy, Group Psychotherapy
D009771
D015928, D011615
Study1: Program materials under development will be shared with research participants in advance. Following the viewing period, online interviews will be conducted. The items to be investigated in the interviews include: 1. Visibility 2. Clarity 3. Accessibility 4. Level of understanding These items were developed specifically for this research.
Study 2: This study is exploratory study which aims to identify appropriate evaluation metrics. Therefore, it will not have a primary endpoint but will conduct evaluations using exploratory endpoints. To assess safety, the study will evaluate dropout rates and adverse events. Additionally, to examine preliminary efficacy, it will assess the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) before and after the intervention.
Study 1: Not applicable.
Study 2: Self-Rated Yale-Brown Obsessive Compulsive Scale (Y-BOCS-SR), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Flourish Scale (FS), UCLA Loneliness Scale, Autism Spectrum Quotient (AQ), and Sheehan Disability Scale (SDS) before and after intervention. Group Cohesion Scale (GCS) after intervention. In addition to the above evaluation items, satisfaction with intervention (Client Satisfaciton Questionnaire: CSQ-8) and homework compliance will also be assessed as part of the feasibility evaluation of group therapy.
none
Intramural Research Grant for Neurological and Psychiatric Disorders, National Center of Neurology and Psychiatry (NCNP)
JSPS KAKENHI Grant-in-Aid for Scientific Research (C)
Institutional Review Board at National Center Hospital for Neurology and Psychiatry
