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Sex differences in the effects of the combined exposure to cephalad fluid shift and mild hypercapnia on cerebral autoregulation

Sex differences in the effects of the combined exposure to cephalad fluid shift and mild hypercapnia on cerebral autoregulation

Iwasaki Kenichi

Nihon University

30-1 Oyaguchi Kamicho Itabashi-ku Tokyo

iwasaki.kenichi@nihon-u.ac.jp

Sugimura Kodai

Nihon University

30-1 Oyaguchi Kamicho Itabashi-ku Tokyo

+81-3-3972-8111

meko23005@g.nihon-u.ac.jp

Recruiting

Mar. 29, 2024

Interventional

non-randomized controlled trial

open(masking not used)

uncontrolled control

single assignment

basic science

1)Persons who are within the age range of 18 to 35 at the time of consent.
2)Persons who have voluntarily consented to participate in this study, after being fully informed and understanding the study.
3)Persons who were determined to be healthy after a medical history and physical examination.
4)Women with menstrual cycles within the normal range (25 to 38 days).
5)Persons who can have a stable brain blood flow velocity waveform displayed by transcranial Doppler sonography in the supine position at rest.

1)Persons who have refused to participate in this study.
2Ppersons deemed ineligible by the principal investigator, such as those taller than 180 cm due to the specifications of the adjustable tilt electric bed.
3)Persons with or a history of cardiovascular diseases (including hypertension and arrhythmia), neurological disorders, respiratory diseases, autonomic nervous system dysfunction, severe systemic diseases, or anemia that has not been improved by treatment (as identified through medical history and physical examination).
4)Persons with a history of hypersensitivity to ultrasound transmission gel or other skin reactions (confirmed by medical interview)
5)Women taking oral contraceptives or other hormonal agents, those with irregular menstrual cycles (outside the normal range of 25 to 38 days), and pregnant women
6)Women whose menstrual cycles make it difficult to schedule experiments during the follicular phase

Both

Attenuated cerebral autoregulation due to microgravity

-10 degree head down tilt and 3% carbon dioxide inhalation

Cerebrovascular circulation

Hypercapnia, Head-Down Tilt

D002560

D006935, D018475

cerebral blood flow velocity in the middle cerebral artery
Index of dynamic cerebral autoregulation : gain, phase, coherence

heart rate, blood pressure, respiratory rate, end-tidal carbon dioxide concentration, percutaneous saturation of arterial oxygen

+81-3-3972-8111

Mar. 19, 2024

No

none