臨床研究等提出・公開システム

Examination of the effect of nasal irrigation in patients with cedar pollinosis

Examination of the effect of nasal irrigation in patients with cedar pollinosis

Masafumi Sakashita

University of Fukui Hospital

23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193 JAPAN

msaka@u-fukui.ac.jp

Tetsuji Takabayashi

University of Fukui Hospital

23-3, Matsuokashimoaizuki, eiheiji-cho, Yoshida-gun, Fukui 910-1193 JAPAN

+81-776-61-8407

tetsuji@u-fukui.ac.jp

Not Recruiting

Jan. 05, 2023

Interventional

single arm study

open(masking not used)

uncontrolled control

single assignment

treatment purpose

1)Faculty members working at the University of Fukui Matsuoka Campus or students enrolled in the University of Fukui Faculty of Medicine
2)A person who can obtain written consent from the person
3)Those who have a positive antigen-specific IgE antibody test at the time of pre-registration test with cedar pollen
4)Those who develop allergic symptoms every year during the cedar pollen allergy season.
5)Those who comply with the compliance rules while participating in this research, undergo medical examinations and examinations specified in this research plan, and are able to report symptoms, etc.

1)People with a nasal irrigation rate of 80% or less
2)In the case of using therapeutic drugs for cedar pollinosis, those who started use, discontinued use, or changed the dosage during the period from 3 days prior to the start of the study to the end of the study.
3) Those who did not take the two tests after registration within the period
4)Persons who are judged by the investigator to be inappropriate for enrollment in this research

Both

cedar pollinosis

Groups A and B only
Rinse the left and right nasal passages twice a day with 50 mL of normal saline or a special cleaning solution

cedar, pollinosis

Nasal irrigarion, saline solution

1006

JRQLQ (Nasal symptom questionnaire)

1)Blood allergy test (total IgE level, antigen-specific IgE level)
2)Background of Research Participants
3)Nasal findings: edema of the nasal mucosa, color of the nasal mucosa, the degree of dryness of the nasal mucosa
4)Intranasal flora
5) Nasal discharge collection: determination of cedar-specific IgE antibodies, albumin, and short-chain fatty acids in nasal secretions, Proteins, peptide mixtures, metabolites of glycolytic systems, amino acids, organic acids, etc.
6)Nasal NO value
7)Comprehensive analysis of genes in nasal mucosal epithelial cells

+81-776-61-8640

Dec. 19, 2022

No

none