臨床研究等提出・公開システム

Date of registration	June. 04, 2026
Last modified on	June. 04, 2026
Trial ID	jRCTs051260068

Scientific Title	Study to Assess Beta Cell Mass in Diabetes Using GLP-1 Receptor Targeted PET Imaging
Public Title	GLP-1 Receptor Targeted PET Imaging Study for Diabetes

Contact for Scientific Queries	Name	Murakami Takaaki
	Affiliation	Kyoto University Graduate School of Medicine
	Address	Yoshida-Konoe-cho, Sakyo-ku, Kyoto
	Telephone	+81-75-751-3560
	E-mail	tounaiei@kuhp.kyoto-u.ac.jp
Contact for Public Queries	Name	Yoshida Hayao
	Affiliation	Kyoto University Graduate School of Medicine
	Address	Yoshida-Konoe-cho, Sakyo-ku, Kyoto
	Telephone	+81-75-751-3560
	E-mail	tounaiei@kuhp.kyoto-u.ac.jp

Recruitment status	Recruiting

Anticipated date of first enrollment		June. 04, 2026
Target sample size		20
Study Type		Interventional
Study Design	allocation	single arm study
	masking	open(masking not used)
	control	uncontrolled control
	assignment	single assignment
	purpose	diagnostic purpose
Key inclusion & exclusion criteria	Inclusion Criteria	i. Individuals diagnosed with diabetes, as well as those clinically determined to be at high risk of developing diabetes. ii. Individuals aged 15 years or older.
	Exclusion Criteria	i. Severe hepatic or renal impairment (AST or ALT > 200 U/L; eGFR < 15 mL/min/1.73 m2) ii. Currently using GLP-1-related products and unable to discontinue them iii. Not suitable for, or has contraindications to, exenatide administration iv. History of alcohol intolerance or severe intolerance to Tween 80 or metoclopramide v. Any other condition deemed inappropriate for participation in this study at the discretion of the principal investigator or sub-investigator(s)
	Age Minimum	15age old over
	Age Maximum	No limit
	Gender	Both
Health Condition(s) or Problem(s) Studied		Diabetes
Intervention(s)		PET imaging using 18F
Health Condition(s) Keyword		Diabetes
Health Condition(s) Code		D003920
Primary Outcome(s)		Pancreatic beta-cell mass
Secondary Outcome(s)		Insulin secretion capacity, blood glucose fluctuations

Name of Certified Review Board	Kyoto University Certified Review Board
Address	53 Shogoin-kawahara-cho, Sakyo-ku, Kyoto
Telephone	+81-75-366-7618
E-Mail	ethcom@kuhp.kyoto-u.ac.jp
Approval Status	Approval
Date of approval	May. 11, 2026

Plan to share IPD	No

Countries of Recruitment（Except Japan）	none