臨床研究等提出・公開システム

Diagnostic laparoscopy with 5-aminolevulinic acid for peritoneal metastasis from colorectal cancer

ALA-CPM

Gohda Yoshimasa

National Center for Global health and Medicine

1-21-1 Toyama, Shinjuku-ku, Tokyo, 161-8655 JAPAN

ygohda@hosp.ncgm.go.jp

Yoshimasa Gohda

National Center for Global health and Medicine

1-21-1 Toyama, Shinjuku-ku, Tokyo, 161-8655 JAPAN

+81-332027181

ygohda@hosp.ncgm.go.jp

Recruiting

May. 28, 2020

Interventional

single arm study

open(masking not used)

uncontrolled control

single assignment

diagnostic purpose

1) Patient diagnosed or suspiciously as peritoneal metastasis from colorectal cancer
2) Patient aged from 20 to 75 years
3) Patient with ECOG performance status of 0 or 1

1) Porphyria. Patients with a history of sun or photosensitivity.
2) Patients with a history of hypersensitivity to porphyrins.
3) Patients taking drugs that may induce photosensitivity.
4) In addition, patients whose physician judged that participation in this study was inappropriate.

Both

peritoneal metastasis from colorectal cancer

3-4 hours before the operation, 1.5 g (20 mg / kg) of araglio granules was dissolved in 50 ml of water and orally administered. Under general anesthesia and insufflation of carbon dioxide gas, the inside of the abdominal cavity is observed using a white and fluorescent light source device. The presence or absence of fluorescence is evaluated using normal light (white light) and blue light.

peritoneal metastasis from colorectal cancer, 5-ALA

Oral administration of 5-ALA

ALA-PDD increases the accuracy of peritoneal metastasis (Comparison of sensitivity between white light and blue light)

Safety

+81-3-3202-7181

May. 21, 2020

none