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Intervention study on the visceral fat reduction by intake of tea catechin and inulin

Intervention study to verify the effect of the changes in intestinal bacteria by intake of tea catechin and inulin on visceral fat reduction

Mikami Tatsuya

Hirosaki University Graduate School of Medicine

5 ZAIFU-CHO, HIROSAKI, AOMORI

tmika@hirosaki-u.ac.jp

Mikami Tatsuya

Hirosaki University Graduate School of Medicine

5 ZAIFU-CHO, HIROSAKI, AOMORI

+81-172-39-5497

tmika@hirosaki-u.ac.jp

Complete

May. 16, 2023

Interventional

randomized controlled trial

double blind

placebo control

parallel assignment

treatment purpose

Those who are participants in the 2023 Iwaki Health Promotion Project Medical Checkup and meet the following inclusion criteria.
-Inclusin criteria-
1. Men and women who are 20 years old or over and under 75 years of age
2. Those with BMI of 23 kg/m2 or more
3. Those with visceral fat area of 80 cm2 or more

1. Those who with hepatic, renal, heart disease, respiratory disorders, digestive disorders, endocrine disorders, metabolic disorders, neuropathy, consciousness disorders, diabetes, hyperlipidemia, hypertension, or other diseases and who are receiving medication treatment and are judged to be inappropriate by a doctor.
2. Those who take diabetes medications such as alpha-glucosidase inhibitors or biguanides that may affect the gut microbiota.
3. Pregnant women (those who plan to become pregnant)
4. Those who work night shifts at least once a week
5. Those who have a history of gastrointestinal resection (excluding appendectomy)
6. Those who have positive HBs antigen markers
7. Those who have positive HCV antibody markers
8. Those who have food allergies
9. Those who are allergic to metal (stainless steel) or have a pacemaker in their body
10. Those who have a history of malignant tumors
11. Those who have a history of mental illness
12. Those who have changes more than 2 kg of weight within 3 months of the start of this study
13. Those who regularly use pharmaceuticals, etc. that may affect the present study
14. Those who donated 200 mL or more of blood within one month of the start of the study, or those who plan to do so during the research period.
15. Those who cannot measure with a visceral fat measuring device
16. Other persons who are judged inappropriate by the principal investigator or the co-investigator

Both

Visceral fat obese

arm 1: Test foods (tea catechin-containing powdered beverage and inulin-containing powdered drink) are ingested once a day for 12 weeks
arm 2:Control foods (placebo powdered drink) are ingested once a day for 12 weeks

Change in the abdominal visceral fat area

1. Changes in the intestinal flora
2. Changes in the waist circumference
3. Changes in the body weight
4. Change in the BMI
5. Change in the body fat ratio
6. Changes in the glucose metabolism-related measurements (Glu, HbA1c, insulin, glycoalbumin)
7. Changes in the lipid metabolism-related measurements (TG, HDL-C, LDL-C)
8. Changes in the blood biochemical test measurements (TP, ALB, GOT, GPT, gamma-GTP, UA, BUN, Cre, CRP, VB12) other than the glucose metabolism-related measurements and the lipid metabolism-related measurements
9. Changes in the hematology test measurements (WBC, RBC, HB, HT, PLT, MCV, MCH, MCHC)
10.Changes in the physiological test measurements (systolic blood pressure, diastolic blood pressure, pulse rate)
11. Changes in the liver fat mass
12.Relationship with the questionnaire items (35 items on dietary habits, FFQ, intestinal regulation related indicators)

+81-172-39-5362

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