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Examination of the effects of renal rehabilitation treatment on kidney transplantation patients

Examination of the effects of renal rehabilitation treatment on kidney transplantation patients

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The study included 23 patients who underwent kidney transplantation at our institution (mean age, 50.4 years; 11 males and 12 females). All patients were 20 years of age or older and participated in perioperative rehabilitation with post-discharge follow-up and exercise guidance. Baseline physical function was classified using the J-CHS criteria as robust (n = 9), pre-frail (n = 6), and frail (n = 8).

A 1-year follow-up from the preoperative to postoperative period was conducted, and early rehabilitation after kidney transplantation, spanning the perioperative phase through post-discharge, was feasible. However, due to postoperative changes in general condition, only a limited number of patients completed all scheduled assessments.

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Due to the small sample size and missing data, the planned statistical analyses could not be fully performed.

Although a 1-year follow-up was conducted, few patients completed all assessments. Therefore, the planned statistical analyses could not be fully performed due to the small sample size and missing data. Nevertheless, this study established a framework for early rehabilitation after kidney transplantation.

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https://jrct.mhlw.go.jp/latest-detail/jRCT1050220180

Domen Kazuhisa

Hyogo Medical University Hospital

1-1, Mukogawa-cho, Nishinomiya, Hyogo

kdomen@mac.com

Ichikawa Masashi

Hyogo Medical University Hospital

1-1, Mukogawa-cho, Nishinomiya, Hyogo

+81-798-45-6881

ma-ichikawa@hyo-med.ac.jp

Complete

May. 01, 2023

Interventional

single arm study

open(masking not used)

uncontrolled control

single assignment

treatment purpose

1. Patients who undergo kidney transplantation at the Department of Urology, Hyogo Medical University Hospital
2. Written informed consent from the patient for study participation
3. Age 20 or older at the time consent is obtained
4. Patients who understand and can parform renal rehabilitation treatment

1. Patient who refused renal rehabilitation treatment
2. Patients with acute myocardial infarction
3. Patients with poorly controlled unstable angina pectoris
4. Patients with poorly controlled arrhythmia
5. Patients with severe aortic stenosis
6. Patients with poorly controlled Heart failure
7. Patients with acute pulmonary embolism or pulmonary infarction
8. Patients with acute myocarditis or pericarditis
9. Patients with acute aortic dissection
10. Patients with mental illness who cannot communicate
11. Patients with poorly controlled hypertension (systolic blood pressure >= 180 mmHg, diastolic blood pressure >= 100 mmHg)
12. Patients with electrolyte imbalance (postoperative serum potassium >=5.5 mEq/L)
13. Patients who are judged unsuitable as subjects by the principal investigator or subinvestigator

Both

Kidney Transplantation

Renal rehabilitation(aerobic exercise, resistance exercise, virtual reality training)
Cardio Pulmonary Exercise test
Body Composition Analyzer
Questionnaire for health related quality of life, and physical activities

End stage renal disease

Renal rehabilitation

D016030

6-minute walk distance

Peak VO2(maximum VO2), Anaerobic Threshold
Gait Speed
Short Physical Performance Battery(as follows: SPPB)
Knee extension strength
eGFR, HGB, Alb
Echocardiography(left ventricular ejection fraction measured, left ventricular end diastolic diameter measured, left atrium diameter measured, left atrium volume measured, E/e' measured)
Ankle brachial pressure index/Pulse Wave Velocity(as follows: ABI/PWV)
Skeletal Muscle mass Index(as follows: SMI)
health-related quality of life, physical activities

+81-798-45-6066

April. 19, 2023

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