臨床研究等提出・公開システム

A diagnosis of pseudo-Cushing's syndrome using dexamethason/CRH and anxiolytic Alprazolam

A diagnosis of pseudo-Cushing's syndrome using dexamethason/CRH and Alprazolam

Takayasu Sinobu

Hirosaki university graduate school of medicine

5 Zaifucho Hirosaki Aomori

stakayas@hirosaki-u.ac.jp

Takayasu Sinobu

Hirosaki-university Hospital

5 Zaifucho Hirosaki Aomori

+81-172-39-5062

stakayas@hirosaki-u.ac.jp

Recruiting

April. 13, 2022

Interventional

single arm study

open(masking not used)

uncontrolled control

single assignment

diagnostic purpose

This study will be conducted in patients with both high basal ACTH and cortisol levels who have a cortisol level of >=3 mcg/dl on a 0.5 mg dexamethasone suppression test or have a midnight cortisol level of >=5 mcg/dl.

Those who are long-term user of steroids should be excluded.
In addition, if the blood glucose of patients is consistently above 300 mg/dl, they should be excluded because dexamethasone may exacerbate hyperglycemia.

Both

Pseudo Cushing's Syndrome

In patients suspected of having Cushing's syndrome or pseudo-Cushing's syndrome, we perform two loading tests, DEX/CRH and alprazolam tests, in order to confirm the differential ability of these tests.

Glucocorticoid , Stress, dexamethasone suppression test

D003480

ACTH, cortisol, salivary cortisol at midnight after administering alprazolam.
Early morning ACTH and cortisol the day after alprazolam oral administration followed by 0.5mg dexamethasone use.
ACTH and cortisol 15 minutes later after administering dexamethasone 0.5 mg every 6 hrs for a total of 8 doses, followed by CRH loading.

Urinary free cortisol in the early morning after administering alprazolam (spot urine)

+81-172-39-5362

Jan. 26, 2022

No

none